* tested more than 8 million common mutations, and found two that seemed to become less prevalent with age. A variant of the APOE gene, which is strongly linked to Alzheimers disease, was rarely found in women over 70. And a mutation in the CHRNA3 gene associated with heavy smoking in men petered out in the population starting in middle age. People without these mutations have a survival edge and are more likely to live longer, the researchers suggest.
* certain groups of genetic mutations, which individually would not have a measurable effect but together accounted for health threats, appeared less often in people who were expected to have long lifespans than in those who weren't. These included predispositions to asthma, high body mass index and high cholesterol.
* Most surprising, however, was the finding that sets of mutations that delay puberty and childbearing are more prevalent in long-lived people.
On more controversial lines, see this http://www.biorxiv.org/content/early/2017/09/06/184853.1 study (N=280,000) that correlates specific genes with IQ.
This is a pretty clear social structure in humans. I understand not all or even most animals have that same social structure. Can someone explain to me why they would assume remaining alive after you dump off your genetic material would be neutral? (from an evolutionary perspective)
> But if that were the case, there would be plenty of such mutations still kicking around in the genome.
So does that mean the gene is less common in children than parents? If so, what does it matter that older people don't have the gene? Why does age factor into this at all?
Considering the extraordinary amount of time it takes for evolution to do anything at all, that they can quantify it in what is relatively zero time in the span of life on Earth, seems to remarkable to be true.
This seems like a lot of speculative leaps to me.
1. assuming that they should necessarily find many of these correlations, absent evolutionary elimination (maybe the effects of individual groups of genes just aren't that strong?)
2. assuming that the lack of them indicates that they existed before and were eliminated (maybe they never existed at all?)
3. more generally, assuming that evolutionary selection is a determining factor in the data they're studying at all (I don't often see noticeable changes in a few generation in highly-contrived genetic algorithms I play with, let alone real-world data which has way, way more noise)
Also "researchers scoured large US and UK genetic databases"- well, I wouldn't be too sure that the biggest part of evolution happening in the human species can be seen inside the UK and US genetic databases.
I assume they're not unknown to science as they're pretty prominent, but then again they're not marked on the Ordnance Survey map as such things tend to be, like the Roman Camps just to their north west for example (http://streetmap.co.uk/grid/375689_566022_120).
Any archaeologists in the house?
It's admittedly debated, but even if just plausible, still fascinating to contemplate.
If not for the wall, there were probably periods in the local history around the pyramids that would qualify. Julius Caesar is closer to our time than he was to the time when they were built. There's a lot of time for people to forget other civilizations in there.
You can read Equifax's original letter in all of its Orwellian double-speak: https://www.regulations.gov/contentStreamer?documentId=CFPB-...
It's absolutely shocking to me how many times they use the words "serve the public interest".
The sell-out that wrote that letter btw is this guy: https://www.cov.com/en/professionals/s/david-stein
When I say the Ferengi* in Star Trek, I found it hilariously unrealistic. Nowadays the possibility of corporations with rights but without responsibility is a scary possible future. Reality can surpass fiction.
Mister Burns style evil.
evil should be punished not rewarded.
(i am already familiar with the phrases: all corporations are like that. everyone is doing it.)
let's reflect for a moment: biggest leak of personal data of us citizens - right after the opm debacle. the same company funds strategies detriment to its customers.
i bet everybody feels like it can't get any worse.
i'm not very old, limited experience but i will predict, brace yourselves, this will go on and on. _nothing_ will change because people don't fucking care and the minority who does care does not have the electorial power it needs to change this system.
i'm waiting for the same thing to happen in germany. it's even worse here because virtually only one company has the monopoly over private credit ratings. everybody is annoyed and _nobody_ cares. we have major elections this month and all those sheep will vote safe.
this is going to be fun. good luck over there, friends.
Probably the most famous and useful is the Shapeshifter , which emulates MacOS on Amiga. It was incredible popular in the 90's, as it allowed to run software otherwise unavailable on AmigaOS (eg. MS Office, Photoshop or games like Warcraft II or Settlers II). What's interesting, Shapeshifter performance was comparable to the real Macintosh running on the same 680x0 as the host Amiga.
PC emulator was called PC-Task  and it wasn't that fast, but I think Windows 3.11 was quite on a 68060-based system.
There's also C64 emulator Frodo  (written by the same developer as Shapeshifter), open source apps ported to Amiga (eg. a800 ) and many others - including all the popular 16-bit console emulators.
Most of these emulators were written in the 90's, so I wouldn't treat them just as a curiosity (as freeflight comment suggest) - they were used and popular amongst Amiga owners, looking for ways to get access to the mainstream software 20 years ago. Usually they required accelerators, as Amiga 1200 with its 68020EC (no FPU) and 2MB RAM was too slow (and forget about A500 or A600).
 http://aminet.net/misc/emu http://shapeshifter.cebix.net/ http://aminet.net/package/misc/emu/PC-Task44 https://frodo.cebix.net/ http://aminet.net/package/misc/emu/A800
Sorry about that, I just couldn't resist ;)
EDIT: Cached version for those that can't open the live link:
> Already Dubrovinskaia and her colleagues have applied this to study osmium, a metal that is among the most resistant to being compressed in the world. They found it could resist compression pressures of over 750 GPa. At this point, the inner electrons, which are normally tightly bound to the nucleus of the metal atom and are highly stable, began to interact with each other. The researchers believe this strange behaviour could lead the metal to change from being a solid into a previously unknown state of matter. They hope to investigate what properties this gives osmium in the future.
Device in question: https://idw-online.de/de/newsimage?id=42938&size=screen
- A non-trivial part of the current contributions included "cheat sheets" which IMO, really required a lot of effort to ensure correctness/usability but don't really provide much improvement to search results(I don't think I myself used the feature in the past 1.5 years more than 3-4 times), so, this should really free up time for DDG staff to focus on the more important instant answers and features.
- The community has been, for a while now, getting smaller and less contributing in the recent past. Backed by data from official repos(the number of commits over time, that is). After all, there are only a finite number of instant answers before they just become redundant.
- The current model for the triggers(when an instant answer gets displayed) is quite restrictive. It's just regex-based. IMO, a lot more growth can be achieved using ML models for triggering, A/B testing etc.
I'm still kind of disappointed with this. Perhaps unrelated, but does anyone have any suggestions for people willing to work on similar open source projects.
: https://github.com/duckduckgo/zeroclickinfo-spice/graphs/con... , https://github.com/duckduckgo/zeroclickinfo-goodies/graphs/c...
If this is not correct, anyone have a link to the exact repo I should be looking at? The link in TFA only goes to the main account page, not any specific repo, and the repo names are not clear enough to tell if they have what I'm looking for.
It's amazing to see so much human effort went into this project and the full 1200-word list. I thought I had read somewhere that this was automation backed by Wikipedia, but apparently it was entirely manual?
I was expecting "hundreds of new bugs".
Best coverage is on Snap Map. Zoom to the Keys and the west coast of Florida and check out the first hand accounts.
also submitted it a bit ago: https://news.ycombinator.com/item?id=15213499
This is a great idea. Love it!
One suggestion Id have is to make photos more prominent. Events like this are mist interesting in the image and short video format.